◆ 主要学习工作经历

●2021年香港科技大学博士学位

●2021年至今在皇冠新款入口工作，特任副教授

●2021年-2023年在香港科技大学从事博士后研究工作

◆ 主要研究内容

主要从事细胞生物学蛋白质胞内运输研究。主要研究方向：1）研究平面细胞极化（Planar cell polarity, PCP）核心蛋白Frizzled-6 从内质网（ER）输出的分子机制；2）研究调控发育过程中重要信号通路因子音猬因子（Sonic hedgehog, Shh）胞内转运过程中的分选及分泌过程的分子机制；3）宿主細胞因子在调控严重急性呼吸系统综合征冠状病毒2（SARS-CoV2）进入宿主细胞过程中作用的研究。

◆ 主要研究课题

1. 国家自然科学基金青年项目，信号分子Sonic hedgehog后高尔基体运输的分子机制，项目编号NSFC 32300589，起止日期1/2024-12/2026，主持。

2. 皇冠新款入口，高层次人才科研启动项目，起止日期2023-2025，主持。

3. 安徽省高等学校科研计划立项，音猬因子从反式高尔基网络输出的分子机制及其对信号转导的影响，项目编号2022AH050174，起止日期2022.12-2025.11，主持。

4. 国家自然科学基金面上项目，平面细胞极化蛋白Frizzled6在早期分泌转运途中运输的分子机制，项目编号NSFC 3207050042，起止日期1/2021-12/2024，参与。

5. 国家自然科学基金面上项目，表皮生长因子从反式高尔基网络运输到细胞膜的分子机制及表皮生长因子受体新靶点的探索，项目编号NSFC 31871421，起止日期1/2019-12/2022，参与。

6. 香港研究资助局基金，Molecular mechanisms regulating the sorting and secretion of sonic hedgehog,项目编号RGC-GRF16102921，起止日期1/2021-12/2023，参与。

◆ 主要研究成果

一、代表性论文及论著：

•Xiao Tang, Rong Chen, Vince St Dollente Mesias, Tingxuan Wang, Ying Wang, Kristina Poljak, Xinyu Fan, Hanchi Miao, Junjie Hu, Liang Zhang, Shuhuai Yao, Elizabeth A. Miller, Yusong Guo. A SURF4-to-proteoglycan relay mechanism that mediates the sorting and secretion of a tagged-variant of sonic hedgehog. Proceedings of the National Academy of Sciences of the United States of America. 2022, 119(11): 1-12.

•Xiao Tang, Tingxuan Wang, Yusong Guo. Export of polybasic motif-containing secretory proteins BMP8A and SFRP1 from the endoplasmic reticulum is regulated by surfeit locus protein 4. The Journal of Biological Chemistry, 2022, 298(12): p. 102687.

•Xiao Tang, Lina Zhang, Tianji Ma, Mo Wang, Baiying Li, Liwen Jiang, Yan Yan, Yusong Guo. Molecular mechanisms that regulate export of the planar cell-polarity protein Frizzled-6 out of the endoplasmic reticulum. Journal of Biological Chemistry. 2020; 295, (27): 8972-8987.

•Xiao Tang^#, Feng Yang^#, Yusong Guo. Cell-free Reconstitution of the Packaging of Cargo Proteins into Vesicles at the trans Golgi Network. Bio-protocol. 2020; 10, (5): e3537.

•Rong Chen, Xiao Tang, Yuxuan Zhao, Zeyu Shen, Meng Zhang, Yusheng Shen, Tiantian Li, Casper Ho Yin Chung, Lijuan Zhang, Ji Wang, Binbin Cui, Peng Fei, Yusong Guo, Shengwang Du, Shuhuai Yao. Single-frame deep-learning super-resolution microscopy for intracellular dynamics imaging. Nature Communications. 2023; 14,(1): 2854.

•Sha Sun, Xiao Tang, Yusong Guo, Junjie Hu. Endoplasmic reticulum composition and form: Proteins in and out. Current Opinion in Cell Biology. 2021; 71: 1-6.

•Vince St Dollente Mesias, Hongni Zhu, Xiao Tang, Xin Dai, Wei Liu, Yusong Guo, Jinqing Huang. Moderate Binding between Two SARS-CoV-2 Protein Segments and α-Synuclein Alters Its Toxic Oligomerization Propensity Differently. J Phys Chem Lett. 2022;13(45):10642-10648.

•Vince St Dollente Mesias, Hongni Zhu, Xiao Tang, Xin Dai, Yusong Guo, Wei Liu, Jinqing Huang. Effective ACE2 peptide-nanoparticle conjugation and its binding with the SARS-Cov-2 RBD quantified by dynamic light scattering. Chem Commun (Camb). 2021; 57(57):6979-6982.

•Yan Huang, Haidi Yin, Baiying Li, Qian Wu, Yang Liu, Kristina Poljak, Julija Maldutyte, Xiao Tang, Mo Wang, Zhixiao Wu, Elizabeth A. Miller, Liwen Jiang, Zhong-Ping Yao, Yusong Guo. An in vitro vesicle formation assay reveals cargo clients and factors that mediate vesicular trafficking. Proceedings of the National Academy of Sciences of the United States of America. 2021; 118(35).

•Liling Niu, Tianji Ma, Feng Yang, Bing Yan, Xiao Tang, Haidi Yin, Qian Wu, Yan Huang, Zhong-Ping Yao, Jifeng Wang, Yusong Guo, Junjie Hu. Atlastin-mediated membrane tethering is critical for cargo mobility and exit from the endoplasmic reticulum. Proceedings of the National Academy of Sciences of the United States of America. 2019; 116, (28): 14029-14038.

•Yusong Guo, Feng Yang, Xiao Tang. Introduction I: An Overview of Protein Secretion in Yeast and Animal Cells. Methods Mol Biol. 2017;1662:1-17.

二、专利：

1. Yusong GUO; Xiao TANG; Tingxuan WANG ; Disruption of Sonic Hedgehog-Surf4 Interaction for Cancer Treatment, 2022-2-14, 美国, 63/309,648 (专利)

三、主要获奖情况：

1. 2019.6  香港校际研究生生物医药研讨会：最佳口头汇报奖

2. 2019.11 香港科技大学研究生研究旅行基金：2019美国细胞生物学年会（ASCB）